Article

Proteomic analysis reveals APOE isoform-specific regulation of ribosomes in neural precursor cells

2023-07-18

Abstract excerpt

<h4>ABSTRACT</h4> ApoE4 isoform contributes to increased risk for Alzheimer’s Disease (AD) over the life course of individuals. Much remains unknown about the biological pathways that connect APOE4 genotype with the development of pathology that eventually leads to AD, nor do we know how early in life these cellular alterations begin. To answer these questions, we derived neural precursor cells (NPCs) from induc...

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Literature Corpus work: 5c72eadf-3188-5f51-be34-d311e00f3a33
DOI: 10.1101/2023.07.15.549177

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