Engineering HIV antibodies with enhanced breadth and potency of neutralization through multistate affinity maturation

Abstract excerpt

Broadly neutralizing antibodies (bnAbs) against HIV hold promise as therapeutic and prophylactic agents, but realizing this potential requires antibodies that function across the antigenic heterogeneity of the HIV envelope glycoprotein (Env). Although numerous bnAbs have been isolated from infected individuals, their breadth and potency may not be sufficient to tackle global viral diversity, motivating efforts to...

Topics

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• AIDS Vaccines
• Antibodies, Neutralizing
• Antibody Affinity
• Broadly Neutralizing Antibodies
• env Gene Products, Human Immunodeficiency Virus
• HIV Antibodies
• Molecular Dynamics Simulation
• Protein Engineering

Identifiers and source

Literature Corpus work

5b3f5ed7-c0b0-5a7b-bff1-05ba27b394fa

DOI

10.1101/2025.10.22.684031