Article

Structural basis for breadth development in a HIV-1 neutralizing antibody

2022-09-15

Abstract excerpt

Antibody affinity maturation enables adaptive immune responses to a wide range of pathogens. In some individuals broadly neutralizing antibodies develop to recognize rapidly mutating pathogens with extensive sequence diversity. Vaccine design for pathogens such as HIV-1 and influenza have therefore focused on recapitulating the natural affinity maturation process. Here, we determined structures of antibodies in co...

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Literature Corpus work: 5f8e871b-e009-5818-a996-972546c45897
DOI: 10.1101/2022.09.14.507935

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