Article
Host-pathogen coevolution and the emergence of broadly neutralizing antibodies in chronic infections
2015-12-20
Abstract excerpt
The vertebrate adaptive immune system provides a flexible and diverse set of molecules to neutralize pathogens. Yet, viruses such as HIV can cause chronic infections by evolving as quickly as the adaptive immune system, forming an evolutionary arms race. Here we introduce a mathematical framework to study the coevolutionary dynamics of antibodies with antigens within a host. We focus on changes in the binding inte...
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Identifiers and source
- Literature Corpus work
- 88345cec-747e-571c-b4e7-9fb9d5989672
- DOI
- 10.1101/034959