Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SARS-CoV-2 Spike Protein Stabilized in the Closed State Induces Potent Neutralizing Responses

6 May 2021

Abstract excerpt

Vaccines in use against SARS-CoV-2 induce immune responses against the spike protein. There is intense interest in whether the antibody response induced by vaccines will be robust against new variants, as well as in next-generation vaccines for use in previously infected or immunized individuals. We assessed the use as an immunogen of a spike protein engineered to be conformationally stabilized in the closed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Virus Infections Studies
Share to SARS-CoV-2 and COVID-19 Research
Share to vaccines and immunoinformatics approaches

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33963055
DOI: 10.1128/jvi.00203-21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 Spike Protein Stabilized in the Closed State Induces Potent Neutralizing ResponsesPMID 33963055Read ↗

SARS-CoV-2 spike protein arrested in the closed state induces potent neutralizing responsesSemantic proximity Read ↗

Impact of SARS-CoV-2 spike stability and RBD exposure on antigenicity and immunogenicitySemantic proximity Read ↗

Mutations of SARS-CoV-2 spike protein: Implications on immune evasion and vaccine-induced immunity.Semantic proximity Read ↗

Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformationSemantic proximity Read ↗

Stabilizing the closed SARS-CoV-2 spike trimer.Semantic proximity Read ↗

Stabilizing the Closed SARS-CoV-2 Spike TrimerSemantic proximity Read ↗

Antibody repertoire induced by SARS-CoV-2 spike protein immunogensSemantic proximity Read ↗

The SARS-CoV-2 Spike Glycoprotein Biosynthesis, Structure, Function, and Antigenicity: Implications for the Design of Spike-Based Vaccine ImmunogensSemantic proximity Read ↗

A thermostable, closed, SARS-CoV-2 spike protein trimerSemantic proximity Read ↗

Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces TrimerizationSemantic proximity Read ↗

A Recombinant Protein SARS-CoV-2 Candidate Vaccine Elicits High-titer Neutralizing Antibodies in Macaques.Semantic proximity Read ↗

Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.