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Article

Domains and Functions of Spike Protein in Sars-Cov-2 in the Context of Vaccine Design.

Viruses - 14 Jan 2021

Xia Xuhua

Abstract excerpt

The spike protein in SARS-CoV-2 (SARS-2-S) interacts with the human ACE2 receptor to gain entry into a cell to initiate infection. Both Pfizer/BioNTech's BNT162b2 and Moderna's mRNA-1273 vaccine candidates are based on stabilized mRNA encoding prefusion SARS-2-S that can be produced after the mRNA is delivered into the human cell and translated. SARS-2-S is cleaved into S1 and S2 subunits, with S1 serving the...

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Share to COVID-19 Vaccines
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Virus

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Share to Spike Glycoprotein, Coronavirus

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Source

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Identifiers

PMID: 33466921
DOI: 10.3390/v13010109
PMCID: PMC7829931

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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