Article

The P3018S disease variant reveals how dynein's trailing motor sets ensemble velocity.

2026-05-18

Abstract excerpt

Mutations in the cytoplasmic dynein heavy chain (DYNC1H1) underlie a range of neurodevelopmental disorders yet how individual variants perturb dynein function remains poorly understood. We characterize the disease-associated P3018S mutation, located in the AAA4 module and within the Lis1-interacting region of the motor. Dynein-dynactin-BicD2 (DDB) complexes containing P3018S dynein move at half the wild-type veloc...

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Literature Corpus work: ead25354-a062-5a4f-b431-003a1a0208f9
DOI: 10.64898/2026.05.14.725143

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