Article

Deciphering epileptogenic and activity-dependent gene programs in the human brain

2026-02-18

Abstract excerpt

Neuronal activity is fundamental to brain function, yet chronically elevated activity underlies neurological disorders such as drug-resistant epilepsy (DRE). In animal models, activity induces defined transcriptional programs within activated neurons; however, the nature, cellular specificity, and pathological relevance of such programs in the human brain remain poorly understood. Here, we apply single-nucleus and...

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Literature Corpus work: ed15edc7-a66d-5653-ab70-c8cd0d3e0f9d
DOI: 10.64898/2026.02.18.706645

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