Article

Single-Nucleus Transcriptomics Reveals Cell Type-Specific Remodeling and Epilepsy-Associated Microglia

2026-03-05

Abstract excerpt

Mesial temporal lobe epilepsy (TLE) is the most common form of acquired epilepsy involving the hippocampus and is a frequent sequelae of head trauma. TLE is associated with refractory seizures and significant cognitive deficits. Yet, the gene expression patterns and cell types driving epileptogenesis and the associated cognitive deficits are poorly understood. To address this, we performed single nucleus RNA seque...

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Literature Corpus work: c4bf6677-c435-5534-8ee8-22f0ff14d1ec
DOI: 10.64898/2026.03.04.709339

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