Article

Electrophysiologically Targeted Biopsies Reveal the Transcriptional Landscape of Focal Epilepsy

2026-03-10

Abstract excerpt

Up to 30% of patients with epilepsy have intractable seizures, yet the mechanisms of focal ictogenesis remain unclear. Tissue involvement in ictal regions is heterogeneous, with different regions playing distinct roles in ictogenesis, seizure propagation, and resistance to spread. These roles are reflected in electrophysiologic differences between the seizure focus and the ictal penumbra, where evidence of synapti...

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Literature Corpus work: 4c0c380d-8b0d-5193-aac7-dd0156db9611
DOI: 10.64898/2026.03.06.708552

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