Article

Gene expression identifies regional central nervous system vulnerability to heat

2026-06-26

Abstract excerpt

Heat-related illness is an increasing global health threat, with heatstroke representing its most severe form and frequently causing cerebellar injury characterised by selective Purkinje neuron loss. The molecular basis of this regional vulnerability remains unclear. Here, we integrated transcriptomic data from human heat exposure experiments, patients with heatstroke, primary human neurons, and cortical organoids...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 93ee6254-01ae-5940-a728-26563a43e697
DOI: 10.64898/2026.06.22.733716

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gene expression identifies regional central nervous system vulnerability to heatDOI 10.64898/2026.06.22.733716Read

Whole genome transcriptomic reveals heat stroke molecular signatures in humansSemantic proximity Read

Profiling the Hsp70 Chaperone Network in Heat-Induced Proteotoxic Stress Models of Human NeuronsSemantic proximity Read

MicroRNA regulation of stress-survival signalling and protein quality control in human heatstrokeSemantic proximity Read

A Model of Exposure to Extreme Environmental Heat Uncovers the Human Transcriptome to Heat StressSemantic proximity Read

Deciphering epileptogenic and activity-dependent gene programs in the human brainSemantic proximity Read

Single-cell sequencing-based study of ferroptosis mechanisms in heat stroke: identification of key biomarkers and dynamic analysis of the immune microenvironmentSemantic proximity Read

Transcriptomics study of hippocampus in mice exposed to heat stress.Semantic proximity Read

Cerebrovascular Single-Nucleus RNA-Seq Reveals Heat Shock Activation and Vascular Remodeling in Alzheimer’s Disease and Primary TauopathiesSemantic proximity Read

Cerebrovascular Single-Nucleus RNA-Seq Reveals Heat Shock Activation and Vascular Remodeling in Alzheimer’s Disease and Primary TauopathiesSemantic proximity Read

Genetic susceptibility to heat identifies rare neurological diseases at particular risk from climate change impacts.Semantic proximity Read

Deciphering the role of heat shock protein HSPA1L: biomarker discovery and prognostic insights in Parkinson's disease and gliomaSemantic proximity Read

HSF1-mediated Proteostasis Decline Links Aging and Sleep DisruptionSemantic proximity Read