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Article

A systems level, functional genomics analysis of chronic epilepsy.

PloS one - 1 Jan 2011

Winden Kellen D, Karsten Stanislav L, Bragin Anatol, Kudo Lili C, Gehman Lauren, Ruidera Josephine, Geschwind Daniel H, Engel Jerome

Abstract excerpt

Neither the molecular basis of the pathologic tendency of neuronal circuits to generate spontaneous seizures (epileptogenicity) nor anti-epileptogenic mechanisms that maintain a seizure-free state are well understood. Here, we performed transcriptomic analysis in the intrahippocampal kainate model of temporal lobe epilepsy in rats using both Agilent and Codelink microarray platforms to characterize the epileptic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21695113
DOI: 10.1371/journal.pone.0020763
PMCID: PMC3114768

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