Article

The gene expression signature of electrical stimulation in the human brain

2023-09-22

Abstract excerpt

Direct electrical stimulation (eSTIM) is widely used clinically, from neurosurgical mapping to therapeutic interventions for neurological and neuropsychiatric disorders 1–10 . Despite over a century of application, its molecular and cellular underpinnings remain unknown. Here, using state-of-the-art single-nuclei multiomic profiling, we map changes in cell-type-specific gene expression and chromatin accessibility...

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Literature Corpus work: 1ec0ae90-7beb-5328-99d5-773868a1ce09
DOI: 10.1101/2023.09.21.558812

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