Neurobehavioral Signatures of Epileptogenesis: Molecular Programs, Trait-like Phenotypes, and Translational Biomarkers Beyond Seizures.

Abstract excerpt

Epileptogenesis is commonly defined by the emergence of spontaneous seizures after an initial insult; however, convergent experimental and clinical evidence indicates that the underlying disease process begins well before seizures become clinically detectable. During this pre-seizure phase, persistent molecular cascades remodel synaptic plasticity, circuit architecture, and glial-immune signaling. These processes...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biomarkers
• Share to Epilepsy
• Share to Neuronal Plasticity