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Clarifying the Impact of Polycomb Complex Component Disruption in Human Cancers

11 Feb 2014

Abstract excerpt

The dysregulation of proper transcriptional control is a major cause of developmental diseases and cancers. Polycomb proteins form chromatin-modifying complexes that transcriptionally silence genome regions in higher eukaryotes. The BCL6 corepressor (BCOR) complex comprises ring finger protein 1B (RNF2/RING1B), polycomb group ring finger 1 (PCGF1), and lysine-specific demethylase 2B (KDM2B) and is uniquely...

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PMID: 24515802
DOI: 10.1158/1541-7786.mcr-13-0596

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