Article

The chromatin remodeler CHD3 is highly expressed in mature neurons and regulates genes involved in synaptic development and function

2024-04-29

Abstract excerpt

Changes in the dynamics of chromatin state that control spatiotemporal gene expression patterns are crucial during brain development. CHD3 is a chromatin remodeler that is highly expressed during neurogenesis and that functions as a core member of the NuRD complex, a large multiprotein complex mediating chromatin state. Genetic disruptions in CHD3 have been implicated in a neurodevelopmental disorder characterize...

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Literature Corpus work: 2dc85008-7b60-5d5f-8b94-01ac74dff0c3
DOI: 10.1101/2024.04.29.591720

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