Article

Minimal Barriers to Invasion During Human Colorectal Tumor Growth

2019-11-14

Abstract excerpt

<h4>ABSTRACT</h4> Intra-tumoral heterogeneity (ITH) could represent clonal evolution where subclones with greater fitness confer more malignant phenotypes and invasion constitutes an evolutionary bottleneck. Alternatively, ITH could represent branching evolution with invasion of multiple subclones. The two models respectively predict a hierarchy of subclones arranged by phenotype, or multiple subclones with share...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ecfe377a-5999-5fbd-82a5-053dbbf83da0
DOI: 10.1101/842203

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Minimal Barriers to Invasion During Human Colorectal Tumor GrowthDOI 10.1101/842203Read

Minimal barriers to invasion during human colorectal tumor growth.Semantic proximity Read

Assessment of the evolutionary consequence of putative driver mutations in colorectal cancer with spatial multiomic dataSemantic proximity Read

Intratumor Heterogeneity and Evolution of Colorectal CancerSemantic proximity Read

New insights into the earliest stages of colorectal tumorigenesis.Semantic proximity Read

Intratumor heterogeneity: A new perspective on colorectal cancer research.Semantic proximity Read

Spatial structure governs the mode of tumour evolutionSemantic proximity Read

Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment.Semantic proximity Read

Tumor Invasive Border Index (TIBI) in colorectal cancer: linking infiltrative morphology to molecular insights.Semantic proximity Read

Prediction of Key Pathological Features in Colorectal Cancer Using a CT-derived Intratumoral Heterogeneity Score (ITHscore)Semantic proximity Read

A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer.Semantic proximity Read

A Big Bang model of human colorectal tumor growthSemantic proximity Read

Lymph node metastases develop through a wider evolutionary bottleneck than distant metastases.Semantic proximity Read