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Article

Minimal barriers to invasion during human colorectal tumor growth.

Nature communications - 9 Mar 2020

Ryser Marc D, Mallo Diego, Hall Allison, Hardman Timothy, King Lorraine M, Tatishchev Sergei, Sorribes Inmaculada C, Maley Carlo C, Marks Jeffrey R, Hwang E Shelley, Shibata Darryl

Abstract excerpt

Intra-tumoral heterogeneity (ITH) could represent clonal evolution where subclones with greater fitness confer more malignant phenotypes and invasion constitutes an evolutionary bottleneck. Alternatively, ITH could represent branching evolution with invasion of multiple subclones. The two models respectively predict a hierarchy of subclones arranged by phenotype, or multiple subclones with shared phenotypes. We...

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Identifiers

PMID: 32152322
DOI: 10.1038/s41467-020-14908-7
PMCID: PMC7062901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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