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Article

Tumor Invasive Border Index (TIBI) in colorectal cancer: linking infiltrative morphology to molecular insights.

The Journal of pathology - 1 Sept 2026

Kehusmaa Akseli, Härkönen Jouni, Li Huayi, Sirniö Päivi, Äijälä Ville K, Karjalainen Henna, Kastinen Meeri, Tapiainen Vilja V, Mantere Tuomo, Pohjanen Vesa-Matti, Elomaa Hanna, Sirkiä Onni, Pasquier Nicolas, Ahtiainen Maarit, Helminen Olli, Wirta Erkki-Ville, Mattila Taneli T, Lindgren Outi, Savela Janette, Rintala Jukka, Meriläinen Sanna, Saarnio Juha, Rautio Tero, Seppälä Toni T, Böhm Jan, Mecklin Jukka-Pekka, Mäkinen Markus J, Tuomisto Anne, Ivaska Johanna, Väyrynen Juha P

Abstract excerpt

Tumor border configuration influences colorectal cancer (CRC) prognosis, yet its molecular determinants remain unclear and existing assessment criteria have faced challenges with reproducibility. We introduce the Tumor Invasive Border Index (TIBI), a novel and reproducible method that quantifies the proportion of tumor stroma and adipose tissue within a hotspot at the deepest point of invasion. TIBI was evaluated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42312545
DOI: 10.1002/path.70087
PMCID: PMC13431732

Genes

DSG3
L1CAM
KRAS
MYC
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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