Article
A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer.
Nature communications - 23 Jul 2018
Saito Tomoko, Niida Atsushi, Uchi Ryutaro, Hirata Hidenari, Komatsu Hisateru, Sakimura Shotaro, Hayashi Shuto, Nambara Sho, Kuroda Yosuke, Ito Shuhei, Eguchi Hidetoshi, Masuda Takaaki, Sugimachi Keishi, Tobo Taro, Nishida Haruto, Daa Tsutomu, Chiba Kenichi, Shiraishi Yuichi, Yoshizato Tetsuichi, Kodama Masaaki, Okimoto Tadayoshi, Mizukami Kazuhiro, Ogawa Ryo, Okamoto Kazuhisa, Shuto Mitsutaka, Fukuda Kensuke, Matsui Yusuke, Shimamura Teppei, Hasegawa Takanori, Doki Yuichiro, Nagayama Satoshi, Yamada Kazutaka, Kato Mamoru, Shibata Tatsuhiro, Mori Masaki, Aburatani Hiroyuki, Murakami Kazunari, Suzuki Yutaka, Ogawa Seishi, Miyano Satoru, Mimori Koshi
Abstract excerpt
Advanced colorectal cancer harbors extensive intratumor heterogeneity shaped by neutral evolution; however, intratumor heterogeneity in colorectal precancerous lesions has been poorly studied. We perform multiregion whole-exome sequencing on ten early colorectal tumors, which contained adenoma and carcinoma in situ. By comparing with sequencing data from advanced colorectal tumors, we show that the early tumors...
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