Article
Lymph node metastases develop through a wider evolutionary bottleneck than distant metastases.
Nature genetics - 1 Jul 2020
Reiter Johannes G, Hung Wei-Ting, Lee I-Hsiu, Nagpal Shriya, Giunta Peter, Degner Sebastian, Liu Gang, Wassenaar Emma C E, Jeck William R, Taylor Martin S, Farahani Alexander A, Marble Hetal D, Knott Simon, Kranenburg Onno, Lennerz Jochen K, Naxerova Kamila
Abstract excerpt
Genetic diversity among metastases is poorly understood but contains important information about disease evolution at secondary sites. Here we investigate inter- and intra-lesion heterogeneity for two types of metastases that associate with different clinical outcomes: lymph node and distant organ metastases in human colorectal cancer. We develop a rigorous mathematical framework for quantifying metastatic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.