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Article

Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment.

Cell - 1 Dec 2006

Anderson Alexander R A, Weaver Alissa M, Cummings Peter T, Quaranta Vito

Abstract excerpt

Emergence of invasive behavior in cancer is life-threatening, yet ill-defined due to its multifactorial nature. We present a multiscale mathematical model of cancer invasion, which considers cellular and microenvironmental factors simultaneously and interactively. Unexpectedly, the model simulations predict that harsh tumor microenvironment conditions (e.g., hypoxia, heterogenous extracellular matrix) exert a...

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Identifiers

PMID: 17129778
DOI: 10.1016/j.cell.2006.09.042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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