Article

Anti-cancer compound screening identifies Aurora Kinase A inhibition as a means to favor CRISPR/Cas9 gene correction over knock-out

2023-11-09

Abstract excerpt

CRISPR gene therapy holds the potential to cure a variety of genetic diseases by targeting causative mutations and introducing double stranded DNA breaks, subsequently allowing the host DNA repair mechanisms to introduce mutations. One option to introduce precise gene corrections is via the homology-directed repair (HDR) pathway. HDR can introduce a range of desired mutations dictated by a DNA template which holds...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3f6614b4-5889-5d42-9076-a7e96aeafc30
DOI: 10.1101/2023.11.09.566375

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Anti-cancer compound screening identifies Aurora Kinase A inhibition as a means to favor CRISPR/Cas9 gene correction over knock-outDOI 10.1101/2023.11.09.566375Read

CRISPR screens guide the way for PARP and ATR inhibitor biomarker discoverySemantic proximity Read

Identifying chemogenetic interactions from CRISPR knockout screens with drugZSemantic proximity Read

Genome editing with the HDR-enhancing DNA-PKcs inhibitor AZD7648 causes large-scale genomic alterationsSemantic proximity Read

Dual genome-wide CRISPR knockout and CRISPR activation screens identify common mechanisms that regulate the resistance to multiple ATR inhibitorsSemantic proximity Read

Chromatin context-dependent effects of epigenetic drugs on CRISPR-Cas9 editingSemantic proximity Read

Focused CRISPR-Cas9 screens investigating the DNA damage responseSemantic proximity Read

Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stressSemantic proximity Read

Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editingSemantic proximity Read

A targeted and tuneable DNA damage tool using CRISPR/Cas9Semantic proximity Read

A scalable platform for efficient CRISPR-Cas9 chemical-genetic screens of DNA damage-inducing compoundsSemantic proximity Read

CRISPR-Cas9 genome editing in human cells works via the Fanconi Anemia pathwaySemantic proximity Read

Identification of Novel Radiosensitizers in a High-Throughput, Cell-Based Screen for DSB Repair InhibitorsSemantic proximity Read