Article

A targeted and tuneable DNA damage tool using CRISPR/Cas9

2021-01-23

Abstract excerpt

<h4>ABSTRACT</h4> Mammalian cells are constantly subjected to a variety of DNA damaging events that lead to the activation of DNA repair pathways. Understanding the molecular mechanisms of the DNA damage response allows the development of therapeutics which target elements of these pathways. Double-Strand Breaks (DSB) are particularly deleterious to cell viability and genome stability. Typically, DSB repair is st...

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Literature Corpus work: cd2923f3-e508-59e2-9256-4c779166ee35
DOI: 10.1101/2021.01.23.427907

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