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CRISPR screens guide the way for PARP and ATR inhibitor biomarker discovery

4 Oct 2021

Abstract excerpt

DNA repair pathways are heavily studied for their role in cancer initiation and progression. Due to the large amount of inherent DNA damage in cancer cells, tumor cells profoundly rely on proper DNA repair for efficient cell cycle progression. Several current chemotherapeutics promote excessive DNA damage in cancer cells, thus leading to cell death during cell cycle progression. However, if the tumor has...

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PMID: 34601817
DOI: 10.1111/febs.16217

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