Article

ASK1 promotes inflammation in senescence and aging

2023-09-21

Abstract excerpt

Cellular senescence is a stress-induced, permanent cell cycle arrest involved in tumor suppression and aging. Senescent cells secrete bioactive molecules such as pro-inflammatory cytokines and chemokines. This senescence-associated secretory phenotype (SASP) has been implicated in immune-mediated elimination of senescent cells and age-associated chronic inflammation. However, the mechanisms regulating the SASP are...

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Literature Corpus work: ecd0bc7f-346e-5cf8-8e89-09368031eccf
DOI: 10.1101/2023.09.20.558729

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