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Article

Age- and Tissue-Specific Expression of Senescence Biomarkers in Mice

22 Feb 2018

Abstract excerpt

Cellular senescence is a state of irreversible cellular growth arrest accompanied by distinct changes in gene expression and the acquisition of a complex proinflammatory secretory profile termed the senescence-associated secretory phenotype (SASP). Senescent cells accumulate in aged tissues and contribute to age-related disease in mice. Increasing evidence that selective removal of senescent cells can ameliorate...

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PMID: 29527222
DOI: 10.3389/fgene.2018.00059

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