Potential Regulators of the Senescence-Associated Secretory Phenotype During Senescence and Aging.

doi:10.1093/gerona/glac097

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Article

Potential Regulators of the Senescence-Associated Secretory Phenotype During Senescence and Aging.

The journals of gerontology. Series A, Biological sciences and medical sciences - 21 Nov 2022

Han Xiaojuan, Lei Qing, Xie Jiamei, Liu Huanhuan, Li Jing, Zhang Xiaohua, Zhang Tianying, Gou Xingchun

Abstract excerpt

Senescent cells express and secrete a variety of extracellular modulators that include cytokines, chemokines, proteases, growth factors, and some enzymes associated with extracellular matrix remodeling, defined as the senescence-associated secretory phenotype (SASP). SASP reinforces senescent cell cycle arrest, stimulates and recruits immune cells for immune-mediated clearance of potentially tumorigenic cells,...

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Share to Advanced biosensing and bioanalysis techniques
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35524726
DOI: 10.1093/gerona/glac097

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