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Article

Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction.

Pharmacological research - 1 Sept 2016

Xu Ming, Tchkonia Tamar, Kirkland James L

Abstract excerpt

Senescent cells accumulate in a variety of tissues with aging. They can develop a senescence-associated secretory phenotype (SASP) that entails secretion of inflammatory cytokines, chemokines, proteases, and growth factors. These SASP components can alter the microenvironment within tissues and affect the function of neighboring cells, which can eventually lead to local and systemic dysfunction. The JAK pathway...

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Identifiers

PMID: 27241018
DOI: 10.1016/j.phrs.2016.05.015
PMCID: PMC5026572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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