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Article

Impact of senescence-associated secretory phenotype and its potential as a therapeutic target for senescence-associated diseases.

Cancer science - 1 Apr 2017

Watanabe Sugiko, Kawamoto Shimpei, Ohtani Naoko, Hara Eiji

Abstract excerpt

"Cellular senescence" is a state in which cells undergo irreversible cell cycle arrest in response to a variety of cellular stresses. Once cells senesce, they are strongly resistant to any mitogens, including oncogenic stimuli. Therefore, cellular senescence has been assumed to be a potent anticancer mechanism. Although irreversible cell-cycle arrest is traditionally considered the major characteristic of...

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Identifiers

PMID: 28165648
DOI: 10.1111/cas.13184
PMCID: PMC5406532

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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