Article

A statistical modelling reveals bi-directional chromatin scanning by RAG in the human TCR-α locus

2020-02-24

Abstract excerpt

Rearrangements of germline variable (V), diversity (D), and joining (J) coding gene segments generate a diverse T cell receptor (TCR) repertoire. Two different molecular mechanisms govern a stochastic nature of gene choices by the recombination activating gene (RAG) protein complex. One is diffusion access in which a chromatin loop containing a coding gene bounces back and forth until the loop encounters a distant...

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Literature Corpus work: ecbb441b-a648-5c0f-9d81-6bf0ff4259d9
DOI: 10.1101/2020.02.21.959197

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