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HLA-focused type 1 diabetes genetic risk prediction in populations of diverse ancestry

2025-08-12

Abstract excerpt

<h4>Aims: </h4>/hypothesis: Type 1 diabetes is characterized by the destruction of pancreatic beta cells. Genetic factors account for ~50% of the total risk, with variants in the Human Leukocyte Antigen (HLA) region contributing to half of this genetic risk, with research historically focused on populations of European ancestry. We developed HLA-focused type 1 diabetes genetic risk scores (T1D GRS HLA ) utilizing...

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Literature Corpus work
ecaf1501-0d7b-5c49-b99a-27096f987e03
DOI
10.1101/2025.08.07.25333167
Open publication

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HLA-focused type 1 diabetes genetic risk prediction in populations of diverse ancestryDOI 10.1101/2025.08.07.25333167
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