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Article

Type 1 diabetes in diverse ancestries and the use of genetic risk scores.

The lancet. Diabetes & endocrinology - 1 Aug 2022

Redondo Maria J, Gignoux Christopher R, Dabelea Dana, Hagopian William A, Onengut-Gumuscu Suna, Oram Richard A, Rich Stephen S

Abstract excerpt

Over 75 genetic loci within and outside of the HLA region influence type 1 diabetes risk. Genetic risk scores (GRS), which facilitate the integration of complex genetic information, have been developed in type 1 diabetes and incorporated into models and algorithms for classification, prognosis, and prediction of disease and response to preventive and therapeutic interventions. However, the development and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35724677
DOI: 10.1016/S2213-8587(22)00159-0
PMCID: PMC10024251

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