Article

Type 1 Diabetes Genetic Risk Score classifies diabetes subtypes in Indians: Impact of HLA diversity on the lower discriminative ability

2024-08-31

Abstract excerpt

<h4>Objectives</h4> Genetic Risk scores (GRS) classify diabetes types, type 1 (T1D) and type 2 (T2D) in Europeans but the power is limited in other ancestries. We explored the performance of T1DGRS and potential reasons for inferior discrimination ability in diabetes-type classification in Indians. <h4>Research Design and Methods</h4> In a well-characterized Indian cohort comprising 645 clinically diagnosed T1D,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b42cfcc8-7306-5ea7-9c41-3c7a7833bc96
DOI: 10.1101/2024.08.31.24312873

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Type 1 Diabetes Genetic Risk Score classifies diabetes subtypes in Indians: Impact of HLA diversity on the lower discriminative abilityDOI 10.1101/2024.08.31.24312873Read

Performance of a Type 1 Diabetes Genetic Risk Score in a Multi-centric Study from India and its Implications in Clinical PracticeSemantic proximity Read

Type 1 diabetes genetic risk score is discriminative of diabetes in non-Europeans: evidence from a study in India.Semantic proximity Read

Type 1 Diabetes Genetic Risk Scores: History, Application and Future Directions.Semantic proximity Read

Type 1 diabetes in diverse ancestries and the use of genetic risk scores.Semantic proximity Read

Clinical and research uses of genetic risk scores in type 1 diabetes.Semantic proximity Read

Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.Semantic proximity Read

HLA-focused type 1 diabetes genetic risk prediction in populations of diverse ancestrySemantic proximity Read

Utility of genetic risk scores in type 1 diabetes.Semantic proximity Read

Improved genetic risk scoring algorithm for type 1 diabetes prediction.Semantic proximity Read

Assessing the prediction of type 2 diabetes risk using polygenic and clinical risk scores in South Asian study populationsSemantic proximity Read

Development and validation of a Trans-Ancestry polygenic risk score for Type 1 DiabetesSemantic proximity Read

Genetic association and machine learning improves discovery and prediction of type 1 diabetesSemantic proximity Read