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Article

Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic Score.

Diabetes - 1 Jan 2026

Deutsch Aaron J, Bell Andrew S, Michalek Dominika A, Burkholder Adam B, Nam Stella, Kreienkamp Raymond J, Sharp Seth A, Huerta-Chagoya Alicia, Mandla Ravi, Nanjala Ruth, Luo Yang, Oram Richard A, Florez Jose C, Onengut-Gumuscu Suna, Rich Stephen S, Ng Maggie C Y, Motsinger-Reif Alison A, Manning Alisa K, Mercader Josep M, Udler Miriam S

Abstract excerpt

Polygenic scores strongly predict type 1 diabetes risk, but most scores were developed in European-ancestry populations. In this study, we leveraged recent multiancestry genome-wide association studies to create a Type 1 Diabetes Multi-Ancestry Polygenic Score (T1D MAPS). We trained the score in the Mass General Brigham (MGB) Biobank (372 individuals with type 1 diabetes) and tested the score in the All of Us...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41236419
DOI: 10.2337/db25-0772
PMCID: PMC12716612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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