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Comparative Evaluation of Cross-Ancestry Polygenic Risk Scoring of Type 1 Diabetes in the All of Us Cohort

2025-10-05

Abstract excerpt

Type 1 diabetes is a highly heritable autoimmune condition characterized by the destruction of pancreatic beta cells, resulting in insulin deficiency. Here, we developed a novel polygenic score we call the HLA-Augmented SBayesRC Framework (HLA-ARC). HLA-ARC integrates direct modeling of HLA haplotypes, with a Bayesian regression approach for the non-HLA component. SBayesRC leverages extensive functional genomic an...

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Literature Corpus work
fc2db7e5-54f9-514b-869b-c1b34460afcc
DOI
10.1101/2025.10.02.25337098
Open publication

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