Development and validation of a trans-ancestry polygenic risk score for type 1 diabetes.

doi:10.1007/s00125-026-06706-5

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Article

Development and validation of a trans-ancestry polygenic risk score for type 1 diabetes.

Diabetologia - 1 Jun 2026

Jumentier Basile, Qu Hui-Qi, Lu Tianyuan, Liu Kai, Kleinbrink Erica L, Klein Kathleen, Belbellaj Wiame, Gamache Isabel, Ferrat Lauric, Butler-Laporte Guillaume, Li Yangxi, Hakonarson Hakon, Wu Wei, Polychronakos Constantin, Greenwood Celia M T, Manousaki Despoina

Abstract excerpt

AIMS/HYPOTHESIS: The high heritability of type 1 diabetes has enabled the development of polygenic risk scores (PRSs) as disease risk screening tools. PRSs can identify individuals at the highest genetic risk in a population, who can benefit from autoantibody and metabolic surveillance, to avoid ketoacidosis at diagnosis and to access preventive therapies. However, PRSs for type 1 diabetes developed from European...

Topics

Female
Humans
Male
Black or African American
Case-Control Studies
Diabetes Mellitus, Type 1
European People
Genetic Predisposition to Disease
Genetic Risk Score

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

Multifactorial Inheritance

Polymorphism, Single Nucleotide

ROC Curve

White People

Hispanic or Latino

East Asian People

Source

Open in PubMed Open full text

Identifiers

PMID: 41795035
DOI: 10.1007/s00125-026-06706-5
PMCID: PMC13109230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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