Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Development and validation of a trans-ancestry polygenic risk score for type 1 diabetes.

Diabetologia - 1 Jun 2026

Jumentier Basile, Qu Hui-Qi, Lu Tianyuan, Liu Kai, Kleinbrink Erica L, Klein Kathleen, Belbellaj Wiame, Gamache Isabel, Ferrat Lauric, Butler-Laporte Guillaume, Li Yangxi, Hakonarson Hakon, Wu Wei, Polychronakos Constantin, Greenwood Celia M T, Manousaki Despoina

Abstract excerpt

AIMS/HYPOTHESIS: The high heritability of type 1 diabetes has enabled the development of polygenic risk scores (PRSs) as disease risk screening tools. PRSs can identify individuals at the highest genetic risk in a population, who can benefit from autoantibody and metabolic surveillance, to avoid ketoacidosis at diagnosis and to access preventive therapies. However, PRSs for type 1 diabetes developed from European...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black or African American
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to East Asian People

Share to European People

Share to Genetic Risk Score

Share to Hispanic or Latino

Share to Multifactorial Inheritance

Share to ROC Curve

Source

Open in PubMed Open full text

Identifiers

PMID: 41795035
DOI: 10.1007/s00125-026-06706-5
PMCID: PMC13109230

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Development and validation of a trans-ancestry polygenic risk score for type 1 diabetes.PMID 41795035Read ↗

Development and validation of a Trans-Ancestry polygenic risk score for Type 1 DiabetesSemantic proximity Read ↗

Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations.Semantic proximity Read ↗

Comparative Evaluation of Cross-Ancestry Polygenic Risk Scoring of Type 1 Diabetes in the All of Us CohortSemantic proximity Read ↗

Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic Score.Semantic proximity Read ↗

Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic ScoreSemantic proximity Read ↗

Validation of a Trans-Ancestry Polygenic Risk Score for Type 2 Diabetes in Diverse PopulationsSemantic proximity Read ↗

Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries.Semantic proximity Read ↗

Integrated clinical risk prediction of type 2 diabetes with a multifactorial polygenic risk scoreSemantic proximity Read ↗

Enabling reproducible type 1 diabetes polygenic risk scoring for clinical and translational applicationsSemantic proximity Read ↗

Standardized Measurement of Type 1 Diabetes Polygenic Risk Across Multi-Ancestry Population CohortsSemantic proximity Read ↗

Assessing the prediction of type 2 diabetes risk using polygenic and clinical risk scores in South Asian study populationsSemantic proximity Read ↗

Type 1 diabetes in diverse ancestries and the use of genetic risk scores.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.