Article
Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.
Scientific reports - 14 Mar 2018
Perry Daniel J, Wasserfall Clive H, Oram Richard A, Williams MacKenzie D, Posgai Amanda, Muir Andrew B, Haller Michael J, Schatz Desmond A, Wallet Mark A, Mathews Clayton E, Atkinson Mark A, Brusko Todd M
Abstract excerpt
Prior studies identified HLA class-II and 57 additional loci as contributors to genetic susceptibility for type 1 diabetes (T1D). We hypothesized that race and/or ethnicity would be contextually important for evaluating genetic risk markers previously identified from Caucasian/European cohorts. We determined the capacity for a combined genetic risk score (GRS) to discriminate disease-risk subgroups in a racially...
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