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Article

HLA-focused type 1 diabetes genetic risk prediction in populations of diverse ancestry.

Diabetologia - 1 Jan 2026

Michalek Dominika A, Tern Courtney, Robertson Catherine C, Chen Wei-Min, Onengut-Gumuscu Suna, Rich Stephen S

Abstract excerpt

AIMS/HYPOTHESIS: Type 1 diabetes is characterised by the destruction of pancreatic beta cells. Genetic factors account for approximately 50% of the total risk, with variants in the HLA region contributing to half of this genetic risk. Research has historically focused on populations of European ancestry. We developed HLA-focused type 1 diabetes genetic risk scores (T1D GRSHLA) using SNPs or HLA alleles from four...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41037100
DOI: 10.1007/s00125-025-06563-8
PMCID: PMC12685975

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