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Article

A multi-ancestry genome-wide association study in type 1 diabetes.

Human molecular genetics - 18 May 2024

Michalek Dominika A, Tern Courtney, Zhou Wei, Robertson Catherine C, Farber Emily, Campolieto Paul, Chen Wei-Min, Onengut-Gumuscu Suna, Rich Stephen S

Abstract excerpt

Type 1 diabetes (T1D) is an autoimmune disease caused by destruction of the pancreatic β-cells. Genome-wide association (GWAS) and fine mapping studies have been conducted mainly in European ancestry (EUR) populations. We performed a multi-ancestry GWAS to identify SNPs and HLA alleles associated with T1D risk and age at onset. EUR families (N = 3223), and unrelated individuals of African (AFR, N = 891) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38453145
DOI: 10.1093/hmg/ddae024
PMCID: PMC11102596

Genes

PTPN22
ERBB3
INS
NRP1
IKZF4
IL2RA
RNLS
RPS26
SH2B3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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