Article

Development and validation of a Trans-Ancestry polygenic risk score for Type 1 Diabetes

2025-06-09

Abstract excerpt

<h4>Objectives</h4> The high heritability of type 1 diabetes has enabled the development of polygenic risk scores (PRS) as disease risk screening tools. PRS can identify individuals at the highest genetic risk in a population, who can benefit from autoantibody and metabolic surveillance, to avoid ketoacidosis at diagnosis and access preventive therapies. However, PRS for type 1 diabetes developed from European dat...

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Literature Corpus work: 15a46d24-b51a-55b8-ae83-9a258082ba57
DOI: 10.1101/2025.06.09.25329166

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