Article
Sex-dependent effects of the targeted nerve growth factor mutation (R100E) on pain behavior, joint inflammation, and bone erosion in mice.
Pain - 1 Dec 2024
Morado-Urbina Carlos E, Kato Jungo, Sandor Katalin, Vazquez-Mora Juan Antonio, Ängeby Möller Kristina, Simon Nils, Salcido Jaira, Martinez-Martinez Arisai, Munoz-Islas Enriqueta, Jimenez-Andrade Juan Miguel, Svensson Camilla I
Abstract excerpt
ABSTRACT: Nerve growth factor (NGF)-R100E is a mutated form of human recombinant NGF that reduces the binding of NGF to its p75NTR receptor while retaining its affinity toward the TrkA receptor. Here, we used human wild type NGF and NGF-R100E knock-in mice to investigate the effects of this NGF mutation on inflammation-induced pain-related behaviors and bone loss. The hNGF-R100E mutation did not alter the nerve...
Topics
- Animals
- Nerve Growth Factor
- Male
- Female
- Mice
- Mutation
- Sex Characteristics
- Inflammation
- Pain
- Mice, Transgenic