Article

Positive and negative control of helicase recruitment at a bacterial chromosome origin

2021-08-16

Abstract excerpt

<h4>ABSTRACT</h4> The mechanisms responsible for helicase loading during the initiation of chromosome replication in bacteria are unclear. Here we report both a positive and a negative mechanism for directing helicase recruitment in the model organism Bacillus subtilis . Systematic mutagenesis of the essential replication initiation gene dnaD and characterization of DnaD variants revealed protein interfaces req...

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Literature Corpus work: ec7d8336-a9b7-558f-a15b-0ab46d805588
DOI: 10.1101/2021.08.16.456468

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