Article
Connecting Replication and Repair: YoaA, a Helicase-Related Protein, Promotes Azidothymidine Tolerance through Association with Chi, an Accessory Clamp Loader Protein.
PLoS genetics - 1 Nov 2015
Brown Laura T, Sutera Vincent A, Zhou Shen, Weitzel Christopher S, Cheng Yisha, Lovett Susan T
Abstract excerpt
Elongating DNA polymerases frequently encounter lesions or structures that impede progress and require repair before DNA replication can be completed. Therefore, directing repair factors to a blocked fork, without interfering with normal replication, is important for proper cell function, and it is a process that is not well understood. To study this process, we have employed the chain-terminating nucleoside...
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