Article
Replication initiation proteins regulate a developmental checkpoint in Bacillus subtilis.
Cell - 26 Jan 2001
Burkholder W F, Kurtser I, Grossman A D
Abstract excerpt
We identified a signaling pathway that prevents initiation of sporulation in Bacillus subtilis when replication initiation is impaired. We isolated mutations that allow a replication initiation mutant (dnaA) to sporulate. These mutations affect a small open reading frame, sda, that was overexpressed in replication initiation mutants and appears to be directly regulated by DnaA. Mutations in replication initiation...
Topics
- Amino Acid Sequence
- Autoradiography
- Bacillus subtilis
- Bacterial Proteins
- Base Sequence
- DNA Helicases
- DNA Replication
- DNA-Binding Proteins
- DnaB Helicases
- Electrophoresis, Polyacrylamide Gel
- Histidine Kinase
- Molecular Sequence Data
- Mutation
- Open Reading Frames