Article

Secreted SARS-CoV-2 ORF8 modulates the cytokine expression profile of human macrophages

2021-08-13

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still adapting to its new human host. Attention has focussed on the viral spike protein, but substantial variation has been seen in the ORF8 gene. Here, we show that SARS-CoV-2 ORF8 protein undergoes signal peptide-mediated processing through the endoplasmic reticulum and is secreted as a glycosylated, disulphide-linked dimer. The secreted protein fr...

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Literature Corpus work: ec459972-86e8-5f8b-8951-df1136c9e471
DOI: 10.1101/2021.08.13.456266

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