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Structural Analysis of SARS-CoV-2 ORF8 Protein: Pathogenic and Therapeutic Implications

6 Sept 2021

Abstract excerpt

Current therapeutic strategies and vaccines against SARS-CoV-2 are mainly focused on the Spike protein despite there are other viral proteins with important roles in COVID-19 pathogenicity. For example, ORF8 restructures vesicular trafficking in the host cell, impacts intracellular immunity through the IFN-I signaling, and growth pathways through the mitogen-activated protein kinases (MAPKs). In this mini-review,...

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PMID: 34552615
DOI: 10.3389/fgene.2021.693227

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