Robust Virus-Specific Adaptive Immunity in COVID-19 Patients with SARS-CoV-2 Δ382 Variant Infection.

doi:10.1007/s10875-021-01142-z

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Article

Robust Virus-Specific Adaptive Immunity in COVID-19 Patients with SARS-CoV-2 Δ382 Variant Infection.

Journal of clinical immunology - 1 Feb 2022

Fong Siew-Wai, Yeo Nicholas Kim-Wah, Chan Yi-Hao, Goh Yun Shan, Amrun Siti Naqiah, Ang Nicholas, Rajapakse Menaka Priyadharsani, Lum Josephine, Foo Shihui, Lee Cheryl Yi-Pin, Carissimo Guillaume, Chee Rhonda Sin-Ling, Torres-Ruesta Anthony, Tay Matthew Zirui, Chang Zi Wei, Poh Chek Meng, Young Barnaby Edward, Tambyah Paul A, Kalimuddin Shirin, Leo Yee-Sin, Lye David C, Lee Bernett, Biswas Subhra, Howland Shanshan Wu, Renia Laurent, Ng Lisa F P

Abstract excerpt

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) that have become dominant as the pandemic progresses bear the ORF8 mutation together with multiple spike mutations. A 382-nucleotide deletion (Δ382) in the ORF7b and ORF8 regions has been associated with milder disease phenotype and less systemic inflammation in COVID-19 patients. However, its impact on host immunity...

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PMID: 34716845
DOI: 10.1007/s10875-021-01142-z
PMCID: PMC8556776

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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