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Article

SARS-CoV-2 ORF8 is a viral cytokine regulating immune responses

2022-08-01

Abstract excerpt

Many patients with severe COVID-19 suffer from pneumonia, and thus elucidation of the mechanisms underlying the development of such severe pneumonia is important. The ORF8 protein is a secreted protein of SARS-CoV-2, whose in vivo function is not well understood. Here, we analyzed the function of ORF8 protein by generating ORF8-knockout SARS-CoV-2. We found that the lung inflammation observed in wild-type SARS-CoV...

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Literature Corpus work
60b63d31-c8e1-5776-8f74-ff911a90d61a
DOI
10.1101/2022.08.01.502275
Open publication

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SARS-CoV-2 ORF8 is a viral cytokine regulating immune responsesDOI 10.1101/2022.08.01.502275
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