Article

Regulation of virion production by the ORF8 signal peptide across SARS-CoV-2 variants

2024-03-06

Abstract excerpt

The open reading frame 8 (ORF8), an accessory protein of SARS-CoV-2, is prone to deletions and mutations across different viral variants, which was first described in several Singapore variants. The reason why viral evolution favors loss or inactivation of ORF8 is not fully understood, although the effects of ORF8 on inflammation, immune evasion, and disease severity have been described. Here we show (using clinic...

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Literature Corpus work: cf53f483-cdf7-55d9-8be6-a1e796b086c7
DOI: 10.1101/2024.03.05.583578

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